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Apr 1, 2025 · Background & Aims Cirrhosis complications are often triggered by bacterial infections with multidrug-resistant organisms. Alterations in the gut and oral microbiome in decompensated cirrhosis (DC) influence clinical outcomes.
Cirrhosis is the result of many years of chronic liver (CLD).1 disease Often silent, CLD slowly changes the liver by restructuring its architecture, combining wound-healing processes, such as remodelling and brosis, with a decrease in the functioning paren-fi chymal mass, which eventually leads to cirrhosis.2 In cirrhosis, which is also silent ...
Aug 9, 2018 · In patients with cirrhosis, the gut microbiome are affected by multiple gut and systemic alterations. These changes lead to dysbiosis in the microbiota of different parts of the body, resulting in inflammation. The constant immune stimulation resulting in part from dysbiosis is associated with morbidity in patients with cirrhosis. Dysbiosis as a dynamic event worsens …
Indeed, evidence that the microbiome reflects decompensated liver cirrhosis was provided in a cohort of 45 liver trans plant recipients, in whom liver transplantation changed the gut microbiome towards increased microbial diver sity, increased autochthonous bacteria (for example, Lachnospiraceae) and decreased potentially pathogenic bacteria ...
Aug 21, 2024 · In summary, our study demonstrated that intestinal microbial disorders of patients with LC exhibited the lack of potentially beneficial microbes, including an overgrowth of potentially pathogenic microbes (bacteria and fungi), which may affect and reflect the clinical features and severity of liver cirrhosis.
Lactobacillus phage Lc Nu and C2-like viruses were negatively linked with beneficial bacteria. Conclusion In this longitudinal study of cirrhosis outpatients, the greatest transkingdom gut microbial changes were seen in those reaching the first decompensation, compared with subsequent decompensating events.
That said, 10% of patients with stable decompensated cirrhosis died within 1 year, having developed either ACLF or complications of portal hypertension. As highlighted above, different microbiota profiles may either benefit or exacerbate the liver phenotype and thereby precipitate decompensation and influence outcome in these patients.
Jan 13, 2025 · Alterations in the gut microbiota and an impaired intestinal barrier are associated with cirrhosis [2]. Changes in the gut‒liver axis disrupt the intestinal barrier, increasing the portal influx of bacteria or their products to the liver and causing …
Jan 9, 2025 · Our systematic review summarizes many microbial changes in cirrhosis, and in most of them, a shift is realized towards an increase in potentially pathogenic or pathogenic bacteria and a significant decrease in commensal or beneficial bacteria.
May 1, 2014 · The gut microbiome is altered in cirrhosis; however its evolution with disease progression is only partly understood. We aimed to study changes in the microbiome over cirrhosis severity, its stability over time and its longitudinal alterations with decompensation.
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